In the global population 60% of people over the age of 30 have periodontal disease. According to the American Veterinary Dental College, periodontal disease is the most common and preventable disease in adult dogs and cats. Periodontal disease begins with dental plaque, the sticky residue that accumulates on teeth from bacteria, mucus and particles in the oral environment. Although gum inflammation is initiated by the bacterial biofilm, progression to periodontal disease results from the host enzymes of the inflammation cascade. Treatment of periodontal disease includes professional dental cleaning or more extensive surgical approaches in severe tooth decay cases.
Current over-the-counter (OTC) and prescription (Rx) periodontal disease treatments target the bacteria responsible for the plaque that develops in the periodontal pockets between the gum and tooth surface. But once the inflammatory process begins in the gum tissue, targeting the inflammatory response of the gingival fibroblasts (or cells of the gums) directly would be a more specific and more effective approach to managing periodontal disease. ECPF-2 can be delivered locally in a mouthwash or gel. In human gum tissue and molars, ECPF-2: